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Year Number of Results
2001 1
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2010 6
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2012 6
2013 12
2014 10
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2017 14
2018 23
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202 results

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Page 1
Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.
Korsunsky I, Wei K, Pohin M, Kim EY, Barone F, Major T, Taylor E, Ravindran R, Kemble S, Watts GFM, Jonsson AH, Jeong Y, Athar H, Windell D, Kang JB, Friedrich M, Turner J, Nayar S, Fisher BA, Raza K, Marshall JL, Croft AP, Tamura T, Sholl LM, Vivero M, Rosas IO, Bowman SJ, Coles M, Frei AP, Lassen K, Filer A, Powrie F, Buckley CD, Brenner MB, Raychaudhuri S. Korsunsky I, et al. Med. 2022 Jul 8;3(7):481-518.e14. doi: 10.1016/j.medj.2022.05.002. Epub 2022 May 31. Med. 2022. PMID: 35649411 Free PMC article.
FINDINGS: Two shared clusters, CXCL10(+)CCL19(+) immune-interacting and SPARC(+)COL3A1(+) vascular-interacting fibroblasts, were expanded in all inflamed tissues and mapped to dermal analogs in a public atopic dermatitis atlas. We confirmed these human pro-inflammatory fib …
FINDINGS: Two shared clusters, CXCL10(+)CCL19(+) immune-interacting and SPARC(+)COL3A1(+) vascular-interacting fibroblasts, were expa …
New insights into the suppression of inflammation and lipid accumulation by JAZF1.
Chen W, Zhong Y, Yuan Y, Zhu M, Hu W, Liu N, Xing D. Chen W, et al. Genes Dis. 2022 Dec 2;10(6):2457-2469. doi: 10.1016/j.gendis.2022.10.029. eCollection 2023 Nov. Genes Dis. 2022. PMID: 37554201 Free PMC article. Review.
JAZF1 is expressed in many tissues and is found at particularly high levels in adipose tissue (AT). JAZF1 suppresses inflammation (including IL-1beta, IL-4, IL-6, IL-8, IL-10, TNFalpha, IFN-gamma, IAR-20, COL3A1, laminin, and MCP-1) by reducing NF-kappaB pathway act …
JAZF1 is expressed in many tissues and is found at particularly high levels in adipose tissue (AT). JAZF1 suppresses inflammation (in …
Revealing stromal and lymphoid sources of Col3a1-expression during inflammation using a novel reporter mouse.
da Rosa LC, Scales HE, Makhija S, Sutherland K, Benson RA, Brewer JM, Garside P. da Rosa LC, et al. Discov Immunol. 2022 Nov 21;1(1):kyac008. doi: 10.1093/discim/kyac008. eCollection 2022. Discov Immunol. 2022. PMID: 38566907 Free PMC article.
Critically, there is still relatively little known regarding the identity of the cell types expressing the gene encoding COL-3 (Col3a1). Identifying and characterizing Col3a1-expressing cells during the development of fibrosis could reveal new targets for the diagno …
Critically, there is still relatively little known regarding the identity of the cell types expressing the gene encoding COL-3 (Col3a1 …
Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis.
Hong SY, Lu YT, Chen SY, Hsu CF, Lu YC, Wang CY, Huang KL. Hong SY, et al. Cell Death Dis. 2023 Jun 8;14(6):352. doi: 10.1038/s41419-023-05876-z. Cell Death Dis. 2023. PMID: 37291088 Free PMC article.
While M2-derived medium promoted the expression of fibroblast-to-myofibroblast transition markers (e.g., ACTA2 and COL3A1), the application of SHP-1 agonist reversed the transition in a dose-dependent manner. ...Our study thus identifies SHP-1 as a druggable target for the …
While M2-derived medium promoted the expression of fibroblast-to-myofibroblast transition markers (e.g., ACTA2 and COL3A1), the appli …
Cardiac fibroblast GSK-3alpha aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis.
Umbarkar P, Ejantkar S, Ruiz Ramirez SY, Toro Cora A, Zhang Q, Tousif S, Lal H. Umbarkar P, et al. Basic Res Cardiol. 2023 Sep 1;118(1):35. doi: 10.1007/s00395-023-01005-1. Basic Res Cardiol. 2023. PMID: 37656238
Specifically, qPCR analysis was performed to examine the gene panels of inflammation (TNFalpha, IL-6, IL-1beta), fibrosis (COL1A1, COL3A1, COMP, Fibronectin-1, Latent TGF-beta binding protein 2), and hypertrophy (ANP, BNP, MYH7). ...
Specifically, qPCR analysis was performed to examine the gene panels of inflammation (TNFalpha, IL-6, IL-1beta), fibrosis (COL1A1, …
Osteopontin Deficiency Ameliorates Prostatic Fibrosis and Inflammation.
Popovics P, Jain A, Skalitzky KO, Schroeder E, Ruetten H, Cadena M, Uchtmann KS, Vezina CM, Ricke WA. Popovics P, et al. Int J Mol Sci. 2021 Nov 18;22(22):12461. doi: 10.3390/ijms222212461. Int J Mol Sci. 2021. PMID: 34830342 Free PMC article.
We found that OPN mRNA and protein expression were significantly induced by E. coli-instillation in the dorsal prostate (DP) after one week in WT mice. Deficiency in OPN expression led to decreased inflammation and fibrosis and the prevention of urinary dysfunction after 8 …
We found that OPN mRNA and protein expression were significantly induced by E. coli-instillation in the dorsal prostate (DP) after one week …
Transcriptome network analysis of inflammation and fibrosis in keloids.
Mao J, Chen L, Qian S, Wang Y, Zhao B, Zhao Q, Lu B, Mao X, Zhai P, Zhang Y, Zhang L, Sun X. Mao J, et al. J Dermatol Sci. 2024 Feb;113(2):62-73. doi: 10.1016/j.jdermsci.2023.12.007. Epub 2023 Dec 27. J Dermatol Sci. 2024. PMID: 38242738
Therefore, a comprehensive understanding of the interactions between cellular inflammation and fibrotic cells is essential to elucidate the mechanisms driving the progression of KL and to develop therapeutics. OBJECTIVE: Investigate the transcriptome landscape of inflam …
Therefore, a comprehensive understanding of the interactions between cellular inflammation and fibrotic cells is essential to elucida …
Severe Burn-Induced Inflammation and Remodeling of Achilles Tendon in a Rat Model.
Hernandez P, Buller D, Mitchell T, Wright J, Liang H, Manchanda K, Welch T, Huebinger RM, Carlson DL, Wolf SE, Song J. Hernandez P, et al. Shock. 2018 Sep;50(3):346-350. doi: 10.1097/SHK.0000000000001037. Shock. 2018. PMID: 29065066 Free PMC article.
Severe burn causes systemic inflammation and hypercatabolism, resulting in damage to multiple organs distant to the burn site, including the musculoskeletal system. ...Gene expression of IL-6 and IL-1beta as well as MMP9 and MMP13 increased in rat tendon 3 days after burn. …
Severe burn causes systemic inflammation and hypercatabolism, resulting in damage to multiple organs distant to the burn site, includ …
Supplemental 25-hydroxycholecalciferol Alleviates Inflammation and Cardiac Fibrosis in Hens.
Chou PC, Chen YH, Chung TK, Walzem RL, Lai LS, Chen SE. Chou PC, et al. Int J Mol Sci. 2020 Nov 8;21(21):8379. doi: 10.3390/ijms21218379. Int J Mol Sci. 2020. PMID: 33171670 Free PMC article.
Supplemental 25-OH-D(3) also ameliorated cardiac fibrosis, endoplasmic reticulum (ER) stress, and autophagy, mostly in Ad-hens, as both collagen content and expression of COL3A1, as well as CCAAT box binding enhancer homologous protein (CHOP) and activating transcription f …
Supplemental 25-OH-D(3) also ameliorated cardiac fibrosis, endoplasmic reticulum (ER) stress, and autophagy, mostly in Ad-hens, as both coll …
Metformin Attenuates Postinfarction Myocardial Fibrosis and Inflammation in Mice.
Loi H, Kramar S, Laborde C, Marsal D, Pizzinat N, Cussac D, Roncalli J, Boal F, Tronchere H, Oleshchuk O, Korda M, Kunduzova O. Loi H, et al. Int J Mol Sci. 2021 Aug 30;22(17):9393. doi: 10.3390/ijms22179393. Int J Mol Sci. 2021. PMID: 34502314 Free PMC article.
Intraperitoneal treatment with metformin (5 mg/kg) was initiated 15 min after the onset of reperfusion and maintained for 14 days. Real-time PCR was used to determine the levels of COL3A1, alphaSMA, CD68, TNF-alpha and IL-6. Increased collagen deposition and infiltration o …
Intraperitoneal treatment with metformin (5 mg/kg) was initiated 15 min after the onset of reperfusion and maintained for 14 days. Real-time …
202 results